CDK1 Regulates Mediator of DNA Damage Checkpoint 1 (MDC1) During Mitotic DNA Damage
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منابع مشابه
CDK1 regulates mediator of DNA damage checkpoint 1 during mitotic DNA damage.
Cells engage sophisticated programs of DNA damage response (DDR) and repair to guard against genetic mutations. Although there is significant knowledge concerning DDR in interphase cells, much less is known about these processes in mitosis. Direct interaction between MDC1, a master DDR organizer, and a marker of DNA damage, histone γH2AX, is required to trigger robust repair. Here we show that ...
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